3brg: Difference between revisions

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New page: left|200px {{Structure |PDB= 3brg |SIZE=350|CAPTION= <scene name='initialview01'>3brg</scene>, resolution 2.20Å |SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+...
 
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[[Image:3brg.jpg|left|200px]]


{{Structure
==CSL (RBP-Jk) bound to DNA==
|PDB= 3brg |SIZE=350|CAPTION= <scene name='initialview01'>3brg</scene>, resolution 2.20&Aring;
<StructureSection load='3brg' size='340' side='right'caption='[[3brg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+For+Residue+C+1'>AC1</scene>, <scene name='pdbsite=AC2:Edo+Binding+Site+For+Residue+C+2'>AC2</scene>, <scene name='pdbsite=AC3:Edo+Binding+Site+For+Residue+C+3'>AC3</scene>, <scene name='pdbsite=AC4:Edo+Binding+Site+For+Residue+C+4'>AC4</scene>, <scene name='pdbsite=AC5:Edo+Binding+Site+For+Residue+C+5'>AC5</scene>, <scene name='pdbsite=AC6:Edo+Binding+Site+For+Residue+C+6'>AC6</scene>, <scene name='pdbsite=AC7:Edo+Binding+Site+For+Residue+C+7'>AC7</scene>, <scene name='pdbsite=AC8:Edo+Binding+Site+For+Residue+C+8'>AC8</scene>, <scene name='pdbsite=AC9:Edo+Binding+Site+For+Residue+C+9'>AC9</scene>, <scene name='pdbsite=BC1:Edo+Binding+Site+For+Residue+C+10'>BC1</scene>, <scene name='pdbsite=BC2:Edo+Binding+Site+For+Residue+C+11'>BC2</scene> and <scene name='pdbsite=BC3:Edo+Binding+Site+For+Residue+C+12'>BC3</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
<table><tr><td colspan='2'>[[3brg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BRG FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE= Rbpj, Igkjrb1, Igkrsbp, Rbpsuh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam09271 LAG1-DNAbind], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01176 IPT_RBP-Jkappa], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam09270 Beta-trefoil]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3brg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3brg OCA], [https://pdbe.org/3brg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3brg RCSB], [https://www.ebi.ac.uk/pdbsum/3brg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3brg ProSAT]</span></td></tr>
|RELATEDENTRY=[[3brd|3BRD]], [[3brf|3BRF]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3brg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3brg OCA], [http://www.ebi.ac.uk/pdbsum/3brg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3brg RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/SUH_MOUSE SUH_MOUSE] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.<ref>PMID:7566092</ref>
 
== Evolutionary Conservation ==
'''CSL (RBP-Jk) bound to DNA'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/3brg_consurf.spt"</scriptWhenChecked>
3BRG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BRG OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3brg ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Friedmann DR]]
[[Category: Friedmann, D R.]]
[[Category: Kovall RA]]
[[Category: Kovall, R A.]]
[[Category: activator]]
[[Category: alternative splicing]]
[[Category: dna binding protein/dna complex]]
[[Category: dna-binding]]
[[Category: notch]]
[[Category: notch signaling pathway]]
[[Category: nucleus]]
[[Category: protein-dna complex]]
[[Category: repressor]]
[[Category: signaling]]
[[Category: transcription]]
[[Category: transcription regulation]]
 
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Retrieved from "https://proteopedia.org/3brg"