3c5h: Difference between revisions

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{{Seed}}
[[Image:3c5h.png|left|200px]]


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==Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP)==
The line below this paragraph, containing "STRUCTURE_3c5h", creates the "Structure Box" on the page.
<StructureSection load='3c5h' size='340' side='right'caption='[[3c5h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3c5h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5H FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
{{STRUCTURE_3c5h|  PDB=3c5h  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5h OCA], [https://pdbe.org/3c5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5h RCSB], [https://www.ebi.ac.uk/pdbsum/3c5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5h ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP)===
== Function ==
 
[https://www.uniprot.org/uniprot/RHG35_HUMAN RHG35_HUMAN] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.<ref>PMID:1894621</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
3C5H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5H OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c5h ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bochkarev, A.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Bochkarev A]]
[[Category: Edwards, A M.]]
[[Category: Bountra C]]
[[Category: MacKenzie, F.]]
[[Category: Edwards AM]]
[[Category: Park, H.]]
[[Category: MacKenzie F]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Park H]]
[[Category: Shen, L.]]
[[Category: Shen L]]
[[Category: Tempel, W.]]
[[Category: Tempel W]]
[[Category: Tong, Y.]]
[[Category: Tong Y]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Alternative splicing]]
[[Category: Anti-oncogene]]
[[Category: Cell cycle]]
[[Category: Cytoplasm]]
[[Category: Dna-binding]]
[[Category: Glucorticoid receptor]]
[[Category: Gtpase]]
[[Category: Gtpase activation]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Ra]]
[[Category: Repressor]]
[[Category: Sgc]]
[[Category: Signaling protein]]
[[Category: Structural genomics consortium]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:11:44 2009''

Latest revision as of 09:33, 21 February 2024

Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP)

3c5h, resolution 1.80Å

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