3c8e: Difference between revisions

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[[Image:3c8e.png|left|200px]]


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==Crystal Structure Analysis of yghU from E. Coli==
The line below this paragraph, containing "STRUCTURE_3c8e", creates the "Structure Box" on the page.
<StructureSection load='3c8e' size='340' side='right'caption='[[3c8e]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3c8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C8E FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
{{STRUCTURE_3c8e|  PDB=3c8e  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c8e OCA], [https://pdbe.org/3c8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c8e RCSB], [https://www.ebi.ac.uk/pdbsum/3c8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c8e ProSAT]</span></td></tr>
 
</table>
===Crystal Structure Analysis of yghU from E. Coli===
== Function ==
 
[https://www.uniprot.org/uniprot/YGHU_ECOLI YGHU_ECOLI] Exhibits a robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert-butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate.
 
== Evolutionary Conservation ==
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/3c8e_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_21222452}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[3c8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C8E OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c8e ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
<ref group="xtra">PMID:21222452</ref><references group="xtra"/>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Armstrong, R N.]]
[[Category: Large Structures]]
[[Category: Harp, J.]]
[[Category: Armstrong RN]]
[[Category: Ladner, J E.]]
[[Category: Harp J]]
[[Category: Schaab, M R.]]
[[Category: Ladner JE]]
[[Category: Stourman, N V.]]
[[Category: Schaab MR]]
[[Category: Stourman NV]]
Retrieved from "https://proteopedia.org/3c8e"