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{{STRUCTURE_3dl8|  PDB=3dl8  |  SCENE=  }}
===Structure of the complex of aquifex aeolicus SecYEG and bacillus subtilis SecA===
{{ABSTRACT_PUBMED_18923516}}


==Function==
==Structure of the complex of aquifex aeolicus SecYEG and bacillus subtilis SecA==
[[http://www.uniprot.org/uniprot/SECG_AQUAE SECG_AQUAE]] Subunit of the protein translocation channel SecYEG. [[http://www.uniprot.org/uniprot/SECA_BACSU SECA_BACSU]] Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity).[HAMAP-Rule:MF_01382] [[http://www.uniprot.org/uniprot/SECY_AQUAE SECY_AQUAE]] The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity).
<StructureSection load='3dl8' size='340' side='right'caption='[[3dl8]], [[Resolution|resolution]] 7.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3dl8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] and [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DL8 FirstGlance]. <br>
[[3dl8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] and [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DL8 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 7.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dl8 OCA], [https://pdbe.org/3dl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dl8 RCSB], [https://www.ebi.ac.uk/pdbsum/3dl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dl8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SECA_BACSU SECA_BACSU] Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity).[HAMAP-Rule:MF_01382]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/3dl8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dl8 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Preprotein translocase|Preprotein translocase]]
*[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]]
*[[SecA|SecA]]
*[[SecA|SecA]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018923516</ref><references group="xtra"/><references/>
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Nam, Y.]]
[[Category: Large Structures]]
[[Category: Rapoport, T A.]]
[[Category: Nam Y]]
[[Category: Zimmer, J.]]
[[Category: Rapoport TA]]
[[Category: Atp-binding]]
[[Category: Zimmer J]]
[[Category: Cell membrane]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Nucleotide-binding]]
[[Category: Protein transport]]
[[Category: Reca-type atpase membrane protein translocation protein-protein complex]]
[[Category: Translocation]]
[[Category: Transmembrane]]
[[Category: Transport]]

Latest revision as of 09:41, 21 February 2024

Structure of the complex of aquifex aeolicus SecYEG and bacillus subtilis SecA

3dl8, resolution 7.50Å

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