3dxt: Difference between revisions

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{{Seed}}
[[Image:3dxt.jpg|left|200px]]


<!--
==Crystal structure of the catalytic core domain of JMJD2D==
The line below this paragraph, containing "STRUCTURE_3dxt", creates the "Structure Box" on the page.
<StructureSection load='3dxt' size='340' side='right'caption='[[3dxt]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3dxt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DXT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3dxt| PDB=3dxt |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dxt OCA], [https://pdbe.org/3dxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dxt RCSB], [https://www.ebi.ac.uk/pdbsum/3dxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dxt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/3dxt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dxt ConSurf].
<div style="clear:both"></div>


===Crystal structure of the catalytic core domain of JMJD2D===
==See Also==
 
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
3DXT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DXT OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, Z.]]
[[Category: Large Structures]]
[[Category: Zhang, G.]]
[[Category: Chen Z]]
[[Category: Chromatin regulator]]
[[Category: Zhang G]]
[[Category: Dioxygenase]]
[[Category: H3k9]]
[[Category: Histone demethylase]]
[[Category: Iron]]
[[Category: Jmjc]]
[[Category: Jmjd2d]]
[[Category: Jumonji domain-containing protein 2d]]
[[Category: Metal-binding]]
[[Category: Nuclear protein]]
[[Category: Nucleus]]
[[Category: Oxidoreductase]]
[[Category: Polymorphism]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  7 14:08:15 2009''
Retrieved from "https://proteopedia.org/3dxt"