3e3u: Difference between revisions

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{{Seed}}
[[Image:3e3u.jpg|left|200px]]


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==Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor==
The line below this paragraph, containing "STRUCTURE_3e3u", creates the "Structure Box" on the page.
<StructureSection load='3e3u' size='340' side='right'caption='[[3e3u]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3e3u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E3U FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=NVC:N-[(2R)-2-{[(2S)-2-(1,3-BENZOXAZOL-2-YL)PYRROLIDIN-1-YL]CARBONYL}HEXYL]-N-HYDROXYFORMAMIDE'>NVC</scene></td></tr>
{{STRUCTURE_3e3u|  PDB=3e3u  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e3u OCA], [https://pdbe.org/3e3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e3u RCSB], [https://www.ebi.ac.uk/pdbsum/3e3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e3u ProSAT]</span></td></tr>
 
</table>
===Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor===
== Function ==
 
[https://www.uniprot.org/uniprot/DEF_MYCTU DEF_MYCTU] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_19008098}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 19008098 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/3e3u_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_19008098}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
3E3U is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E3U OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e3u ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
<ref group="xtra">PMID:19008098</ref><references group="xtra"/>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Peptide deformylase]]
[[Category: Koehn J]]
[[Category: Koehn, J.]]
[[Category: Meng W]]
[[Category: Meng, W.]]
[[Category: Pan S]]
[[Category: Pan, S.]]
[[Category: Xu M]]
[[Category: Xu, M.]]
[[Category: Hydrolase]]
[[Category: Iron]]
[[Category: Metal-binding]]
[[Category: Metallo-enzyme]]
[[Category: Protein biosynthesis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:45:31 2009''

Latest revision as of 09:44, 21 February 2024

Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor

3e3u, resolution 1.56Å

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