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[[Image:3eq4.png|left|200px]]


{{STRUCTURE_3eq4|  PDB=3eq4  |  SCENE=  }}
==Model of tRNA(Leu)-EF-Tu in the ribosomal pre-accommodated state revealed by cryo-EM==
 
<SX load='3eq4' size='340' side='right' viewer='molstar' caption='[[3eq4]], [[Resolution|resolution]] 12.00&Aring;' scene=''>
===Model of tRNA(Leu)-EF-Tu in the ribosomal pre-accommodated state revealed by cryo-EM===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3eq4]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EQ4 FirstGlance]. <br>
{{ABSTRACT_PUBMED_19020518}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 12&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eq4 OCA], [https://pdbe.org/3eq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eq4 RCSB], [https://www.ebi.ac.uk/pdbsum/3eq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eq4 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[3eq4]] is a 9 chain structure of [[Ribosomal protein L11]] and [[Ribosomal protein S12]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EQ4 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/RL11_ECOLI RL11_ECOLI] This protein binds directly to 23S ribosomal RNA. Forms the L11 stalk, which is mobile in the ribosome, indicating its contribution to the activity of initiation, elongation and release factors.[HAMAP-Rule:MF_00736_B]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eq/3eq4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eq4 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ribosomal protein L11|Ribosomal protein L11]]
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
*[[Ribosomal protein L11 3D structures|Ribosomal protein L11 3D structures]]
*[[Ribosomal protein S12|Ribosomal protein S12]]
*[[Ribosomal protein S12|Ribosomal protein S12]]
 
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
==Reference==
__TOC__
<ref group="xtra">PMID:019020518</ref><references group="xtra"/>
</SX>
[[Category: Escherichia coli k12]]
[[Category: Escherichia coli K-12]]
[[Category: Agirrezabala, X.]]
[[Category: Large Structures]]
[[Category: Frank, J.]]
[[Category: Agirrezabala X]]
[[Category: Li, W.]]
[[Category: Frank J]]
[[Category: A/t-trna]]
[[Category: Li W]]
[[Category: Antibiotic resistance]]
[[Category: Automated data collection]]
[[Category: Elongation factor]]
[[Category: Gtp-binding]]
[[Category: Membrane]]
[[Category: Methylation]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Protein biosynthesis]]
[[Category: Protein translation]]
[[Category: Ribonucleoprotein]]
[[Category: Ribosomal protein]]
[[Category: Ribosomal protein-rna complex]]
[[Category: Rna-binding]]
[[Category: Rrna-binding]]
[[Category: Ternary complex]]
[[Category: Trna-binding]]

Latest revision as of 09:49, 21 February 2024

Model of tRNA(Leu)-EF-Tu in the ribosomal pre-accommodated state revealed by cryo-EM

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