3ft8: Difference between revisions

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[[Image:3ft8.png|left|200px]]


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==Structure of HSP90 bound with a noval fragment.==
The line below this paragraph, containing "STRUCTURE_3ft8", creates the "Structure Box" on the page.
<StructureSection load='3ft8' size='340' side='right'caption='[[3ft8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ft8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FT8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MOJ:(5E,7S)-2-AMINO-7-(4-FLUORO-2-PYRIDIN-3-YLPHENYL)-4-METHYL-7,8-DIHYDROQUINAZOLIN-5(6H)-ONE+OXIME'>MOJ</scene></td></tr>
{{STRUCTURE_3ft8|  PDB=3ft8  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ft8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ft8 OCA], [https://pdbe.org/3ft8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ft8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ft8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ft8 ProSAT]</span></td></tr>
 
</table>
===Structure of HSP90 bound with a noval fragment.===
== Function ==
 
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
 
== Evolutionary Conservation ==
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/3ft8_consurf.spt"</scriptWhenChecked>
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==About this Structure==
  </jmolCheckbox>
[[3ft8]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FT8 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ft8 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Heat Shock Proteins]]
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:19301319</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Barker, J B.]]
[[Category: Large Structures]]
[[Category: Cheng, R K.Y.]]
[[Category: Barker JB]]
[[Category: Felicetti, B.]]
[[Category: Cheng RKY]]
[[Category: Palan, S.]]
[[Category: Felicetti B]]
[[Category: Alternative splicing]]
[[Category: Palan S]]
[[Category: Atp-binding]]
[[Category: Chaperone]]
[[Category: Cytoplasm]]
[[Category: Hsp90 n-terminal nucleotide binding domain]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Stress response]]
Retrieved from "https://proteopedia.org/3ft8"