3fwe: Difference between revisions

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{{Seed}}
[[Image:3fwe.png|left|200px]]


<!--
==Crystal Structure of the Apo D138L CAP mutant==
The line below this paragraph, containing "STRUCTURE_3fwe", creates the "Structure Box" on the page.
<StructureSection load='3fwe' size='340' side='right'caption='[[3fwe]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3fwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWE FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
{{STRUCTURE_3fwe| PDB=3fwe |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwe OCA], [https://pdbe.org/3fwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fwe RCSB], [https://www.ebi.ac.uk/pdbsum/3fwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/3fwe_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fwe ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the Apo D138L CAP mutant===
==See Also==
 
*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
3FWE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWE OCA].
__TOC__
[[Category: Escherichia coli k-12]]
</StructureSection>
[[Category: Kong, J.]]
[[Category: Escherichia coli K-12]]
[[Category: Sharma, H.]]
[[Category: Large Structures]]
[[Category: Steitz, T.]]
[[Category: Kong J]]
[[Category: Wang, J.]]
[[Category: Sharma H]]
[[Category: Yu, S.]]
[[Category: Steitz T]]
[[Category: Acetylation]]
[[Category: Wang J]]
[[Category: Activator]]
[[Category: Yu S]]
[[Category: Allostery]]
[[Category: Camp]]
[[Category: Camp-binding]]
[[Category: Dna-binding]]
[[Category: Helix-turn-helix]]
[[Category: Nucleotide-binding]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulator]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:31:12 2009''
Retrieved from "https://proteopedia.org/3fwe"