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[[Image:3gtc.png|left|200px]]


{{STRUCTURE_3gtc|  PDB=3gtc  |  SCENE=  }}
==AmpC beta-lactamase in complex with Fragment-based Inhibitor==
 
<StructureSection load='3gtc' size='340' side='right'caption='[[3gtc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===AmpC beta-lactamase in complex with Fragment-based Inhibitor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3gtc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GTC FirstGlance]. <br>
{{ABSTRACT_PUBMED_19416920}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTC:(1R,2S)-2-(5-THIOXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)CYCLOHEXANECARBOXYLIC+ACID'>GTC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gtc OCA], [https://pdbe.org/3gtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gtc RCSB], [https://www.ebi.ac.uk/pdbsum/3gtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gtc ProSAT]</span></td></tr>
[[3gtc]] is a 2 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GTC OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/3gtc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gtc ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Beta-lactamase|Beta-lactamase]]
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:019416920</ref><references group="xtra"/>
[[Category: Escherichia coli K-12]]
[[Category: Beta-lactamase]]
[[Category: Large Structures]]
[[Category: Escherichia coli]]
[[Category: Shoichet BK]]
[[Category: Shoichet, B K.]]
[[Category: Teotico DT]]
[[Category: Teotico, D T.]]
[[Category: Antibiotic resistance]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
Retrieved from "https://proteopedia.org/3gtc"