3hb5: Difference between revisions

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New page: '''Unreleased structure''' The entry 3hb5 is ON HOLD Authors: Mazumdar, M., Lin, S.-X. Description: Binary and ternary crystal structures of a novel inhibitor of 17 -HSD type 1: a lead...
 
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'''Unreleased structure'''


The entry 3hb5 is ON HOLD
==Binary and ternary crystal structures of a novel inhibitor of 17 beta-HSD type 1: a lead compound for breast cancer therapy==
<StructureSection load='3hb5' size='340' side='right'caption='[[3hb5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3hb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HB5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E2B:3-{[(9BETA,14BETA,16ALPHA,17ALPHA)-3,17-DIHYDROXYESTRA-1,3,5(10)-TRIEN-16-YL]METHYL}BENZAMIDE'>E2B</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hb5 OCA], [https://pdbe.org/3hb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hb5 RCSB], [https://www.ebi.ac.uk/pdbsum/3hb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hb5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/3hb5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hb5 ConSurf].
<div style="clear:both"></div>


Authors: Mazumdar, M., Lin, S.-X.
==See Also==
 
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
Description: Binary and ternary crystal structures of a novel inhibitor of 17 -HSD type 1: a lead compound for breast cancer therapy
__TOC__
 
</StructureSection>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 09:37:17 2009''
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lin S-X]]
[[Category: Mazumdar M]]
Retrieved from "https://proteopedia.org/3hb5"