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[[Image:3jso.png|left|200px]]


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==Classic Protein With a New Twist: crystal structure of a LexA repressor DNA complex==
The line below this paragraph, containing "STRUCTURE_3jso", creates the "Structure Box" on the page.
<StructureSection load='3jso' size='340' side='right'caption='[[3jso]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3jso]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jso OCA], [https://pdbe.org/3jso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jso RCSB], [https://www.ebi.ac.uk/pdbsum/3jso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jso ProSAT]</span></td></tr>
{{STRUCTURE_3jso|  PDB=3jso  |  SCENE=  }}
</table>
 
== Function ==
===Classic Protein With a New Twist: crystal structure of a LexA repressor DNA complex===
[https://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
<!--
Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_20703307}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 20703307 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jso_consurf.spt"</scriptWhenChecked>
-->
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_20703307}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jso ConSurf].
[[3jso]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSO OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:020703307</ref><references group="xtra"/>
__TOC__
[[Category: Escherichia coli k-12]]
</StructureSection>
[[Category: Repressor lexA]]
[[Category: Escherichia coli K-12]]
[[Category: Pigli, Y Z.]]
[[Category: Large Structures]]
[[Category: Rice, P A.]]
[[Category: Pigli YZ]]
[[Category: Zhang, A P.P.]]
[[Category: Rice PA]]
[[Category: Autocatalytic cleavage]]
[[Category: Zhang APP]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Dna replication]]
[[Category: Dna-binding]]
[[Category: Double helix]]
[[Category: Hydrolase]]
[[Category: Hydrolase-dna complex]]
[[Category: Lexa]]
[[Category: Protein-dna complex]]
[[Category: Repressor]]
[[Category: Sos response]]
[[Category: Sos system]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Winged helix-turn-helix]]

Latest revision as of 10:13, 21 February 2024

Classic Protein With a New Twist: crystal structure of a LexA repressor DNA complex

3jso, resolution 2.29Å

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