3k0j: Difference between revisions

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{{Seed}}
[[Image:3k0j.png|left|200px]]


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==Crystal structure of the E. coli ThiM riboswitch in complex with thiamine pyrophosphate and the U1A crystallization module==
The line below this paragraph, containing "STRUCTURE_3k0j", creates the "Structure Box" on the page.
<StructureSection load='3k0j' size='340' side='right'caption='[[3k0j]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3k0j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K0J FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
{{STRUCTURE_3k0j| PDB=3k0j |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k0j OCA], [https://pdbe.org/3k0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k0j RCSB], [https://www.ebi.ac.uk/pdbsum/3k0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k0j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/3k0j_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k0j ConSurf].
<div style="clear:both"></div>


===Crystal structure of the E. coli ThiM riboswitch in complex with thiamine pyrophosphate and the U1A crystallization module===
==See Also==
 
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
 
*[[Riboswitch 3D structures|Riboswitch 3D structures]]
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== References ==
The line below this paragraph, {{ABSTRACT_PUBMED_19948769}}, adds the Publication Abstract to the page
<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 19948769 is the PubMed ID number.
__TOC__
-->
</StructureSection>
{{ABSTRACT_PUBMED_19948769}}
[[Category: Escherichia coli]]
 
==About this Structure==
3K0J is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K0J OCA].
 
==Reference==
<ref group="xtra">PMID:19948769</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Large Structures]]
[[Category: Edwards, T E.]]
[[Category: Edwards TE]]
[[Category: Kulshina, N.]]
[[Category: Ferre-D'Amare AR]]
[[Category: Acetylation]]
[[Category: Kulshina N]]
[[Category: Mrna processing]]
[[Category: Mrna splicing]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Ribonucleoprotein]]
[[Category: Riboswitch]]
[[Category: Rna]]
[[Category: Rna-binding]]
[[Category: Rna/rna binding protein complex]]
[[Category: Spliceosome]]
[[Category: Thi-box]]
[[Category: Thim]]
[[Category: U1a protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 12:40:19 2010''
Retrieved from "https://proteopedia.org/3k0j"