3k2z: Difference between revisions

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{{STRUCTURE_3k2z|  PDB=3k2z  |  SCENE=  }}
===Crystal structure of a LexA protein from Thermotoga maritima===


==Function==
==Crystal structure of a LexA protein from Thermotoga maritima==
[[http://www.uniprot.org/uniprot/LEXA_THEMA LEXA_THEMA]] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity).  
<StructureSection load='3k2z' size='340' side='right'caption='[[3k2z]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3k2z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K2Z FirstGlance]. <br>
[[3k2z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2Z OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37&#8491;</td></tr>
[[Category: Repressor lexA]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k2z OCA], [https://pdbe.org/3k2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k2z RCSB], [https://www.ebi.ac.uk/pdbsum/3k2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k2z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEXA_THEMA LEXA_THEMA] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/3k2z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k2z ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Rice, P A.]]
[[Category: Rice PA]]
[[Category: Zhang, A P.P.]]
[[Category: Zhang APP]]
[[Category: Autocatalytic cleavage]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Dna replication]]
[[Category: Dna-binding]]
[[Category: Hydrolase]]
[[Category: Lexa]]
[[Category: Repressor]]
[[Category: Sos response]]
[[Category: Sos system]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Winged helix-turn-helix]]
Retrieved from "https://proteopedia.org/3k2z"