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{{STRUCTURE_3k3r|  PDB=3k3r  |  SCENE=  }}
===Unrefined crystal structure of a LexA-DNA complex===
{{ABSTRACT_PUBMED_020703307}}


==Function==
==Unrefined crystal structure of a LexA-DNA complex==
[[http://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI]] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref>
<StructureSection load='3k3r' size='340' side='right'caption='[[3k3r]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3k3r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K3R FirstGlance]. <br>
[[3k3r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3R OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k3r OCA], [https://pdbe.org/3k3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k3r RCSB], [https://www.ebi.ac.uk/pdbsum/3k3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k3r ProSAT]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:020703307</ref><references group="xtra"/><references/>
== Function ==
[[Category: Escherichia coli k-12]]
[https://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref>  
[[Category: Repressor lexA]]
== Evolutionary Conservation ==
[[Category: Pigli, Y Z.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Rice, P A.]]
Check<jmol>
[[Category: Zhang, A P.P.]]
  <jmolCheckbox>
[[Category: Autocatalytic cleavage]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k3/3k3r_consurf.spt"</scriptWhenChecked>
[[Category: Dna damage]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Dna repair]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Dna replication]]
  </jmolCheckbox>
[[Category: Dna-binding]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k3r ConSurf].
[[Category: Double helix]]
<div style="clear:both"></div>
[[Category: Hydrolase]]
== References ==
[[Category: Hydrolase-dna complex]]
<references/>
[[Category: Lexa]]
__TOC__
[[Category: Protein-dna complex]]
</StructureSection>
[[Category: Repressor]]
[[Category: Escherichia coli K-12]]
[[Category: Sos response]]
[[Category: Large Structures]]
[[Category: Sos system]]
[[Category: Pigli YZ]]
[[Category: Transcription]]
[[Category: Rice PA]]
[[Category: Transcription regulation]]
[[Category: Zhang APP]]
[[Category: Winged helix-turn-helix]]
Retrieved from "https://proteopedia.org/3k3r"