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[[Image:3kd9.png|left|200px]]


{{STRUCTURE_3kd9|  PDB=3kd9  |  SCENE=  }}
==Crystal structure of pyridine nucleotide disulfide oxidoreductase from Pyrococcus horikoshii==
 
<StructureSection load='3kd9' size='340' side='right'caption='[[3kd9]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
===Crystal structure of pyridine nucleotide disulfide oxidoreductase from Pyrococcus horikoshii===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3kd9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KD9 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[3kd9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KD9 OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kd9 OCA], [https://pdbe.org/3kd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kd9 RCSB], [https://www.ebi.ac.uk/pdbsum/3kd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kd9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NCPPR_PYRHO NCPPR_PYRHO] Catalyzes the NAD(P)H-dependent reduction of polysulfide, CoA-polysulfides, and CoA persulfide, as well as the reduction of a range of other small persulfides, including TNB and glutathione persulfides. The likely in vivo substrates are di-, poly-, and persulfide derivatives of coenzyme A, although polysulfide itself is also efficiently reduced (PubMed:23530771). Shows coenzyme A disulfide reductase (CoADR) activity with both NADH and NADPH, with a preference for NADPH (PubMed:15720393). May also play a role in the reduction of elemental sulfur (PubMed:23530771).<ref>PMID:15720393</ref> <ref>PMID:23530771</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/3kd9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kd9 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Coenzyme A-Disulfide Reductase|Coenzyme A-Disulfide Reductase]]
*[[Coenzyme A-Disulfide Reductase|Coenzyme A-Disulfide Reductase]]
[[Category: CoA-disulfide reductase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii]]
[[Category: Agarwal, R.]]
[[Category: Agarwal R]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
[[Category: Swaminathan S]]
[[Category: Swaminathan, S.]]
[[Category: 11140o]]
[[Category: Fad]]
[[Category: Flavoprotein]]
[[Category: Nad]]
[[Category: New york sgx research center for structural genomic]]
[[Category: Nysgxrc]]
[[Category: Oxidoreductase]]
[[Category: Protein structure initiative]]
[[Category: Psi-ii]]
[[Category: Redox-active center]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/3kd9"