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{{STRUCTURE_3kl4|  PDB=3kl4  |  SCENE=  }}
===Recognition of a signal peptide by the signal recognition particle===
{{ABSTRACT_PUBMED_20364120}}


==Function==
==Recognition of a signal peptide by the signal recognition particle==
[[http://www.uniprot.org/uniprot/SRP54_SULSO SRP54_SULSO]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).  
<StructureSection load='3kl4' size='340' side='right'caption='[[3kl4]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3kl4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KL4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kl4 OCA], [https://pdbe.org/3kl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kl4 RCSB], [https://www.ebi.ac.uk/pdbsum/3kl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kl4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SRP54_SACS2 SRP54_SACS2] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.[HAMAP-Rule:MF_00306]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3kl4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kl4 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
[[3kl4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL4 OCA].
*[[Signal recognition particle 3D structures|Signal recognition particle 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:020364120</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Saccharolobus solfataricus P2]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Signal-recognition-particle GTPase]]
[[Category: Janda CY]]
[[Category: Sulfolobus solfataricus p2]]
[[Category: Li J]]
[[Category: Janda, C Y.]]
[[Category: Nagai K]]
[[Category: Li, J.]]
[[Category: Oubridge C]]
[[Category: Nagai, K.]]
[[Category: Oubridge, C.]]
[[Category: Ffh]]
[[Category: Gtp-binding]]
[[Category: Hydrolase]]
[[Category: Nucleotide-binding]]
[[Category: Ribonucleoprotein]]
[[Category: Rna-binding]]
[[Category: Signal peptide]]
[[Category: Signal recognition particle]]
[[Category: Signal sequence]]
[[Category: Signal-anchor]]
[[Category: Srp]]
[[Category: Srp54]]
[[Category: Transmembrane]]
Retrieved from "https://proteopedia.org/3kl4"