3ks4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:3ks4.jpg|left|200px]]


<!--
==Crystal structure of Reston ebolavirus VP35 RNA binding domain==
The line below this paragraph, containing "STRUCTURE_3ks4", creates the "Structure Box" on the page.
<StructureSection load='3ks4' size='340' side='right'caption='[[3ks4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ks4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston Reston ebolavirus - Reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KS4 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ks4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ks4 OCA], [https://pdbe.org/3ks4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ks4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ks4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ks4 ProSAT]</span></td></tr>
{{STRUCTURE_3ks4|  PDB=3ks4  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of Reston ebolavirus VP35 RNA binding domain===
[https://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
<!--
Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_20018665}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 20018665 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/3ks4_consurf.spt"</scriptWhenChecked>
-->
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_20018665}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ks4 ConSurf].
3KS4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS4 OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:20018665</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Reston ebolavirus]]
[[Category: Reston ebolavirus - Reston]]
[[Category: Bornholdt, Z A.]]
[[Category: Bornholdt ZA]]
[[Category: Kimberlin, C R.]]
[[Category: Kimberlin CR]]
[[Category: Li, S.]]
[[Category: Li S]]
[[Category: Macrae, I J.]]
[[Category: Macrae IJ]]
[[Category: Saphire, E O.]]
[[Category: Saphire EO]]
[[Category: Woods, V L.]]
[[Category: Woods VL]]
[[Category: Ebolavirus]]
[[Category: Host cytoplasm]]
[[Category: Interferon]]
[[Category: Interferon antiviral system evasion]]
[[Category: Protein-rna complex]]
[[Category: Reston]]
[[Category: Rna replication]]
[[Category: Rna-binding]]
[[Category: Rna-binding protein]]
[[Category: Transcription]]
[[Category: Virion]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:15:05 2010''
Retrieved from "https://proteopedia.org/3ks4"