3odk: Difference between revisions

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{{Seed}}
[[Image:3odk.png|left|200px]]


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==Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution==
The line below this paragraph, containing "STRUCTURE_3odk", creates the "Structure Box" on the page.
<StructureSection load='3odk' size='340' side='right'caption='[[3odk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3odk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ODK:3-PYRIDIN-2-YL-1H-PYRAZOLE-5-CARBOXYLIC+ACID'>ODK</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
{{STRUCTURE_3odk|  PDB=3odk  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odk OCA], [https://pdbe.org/3odk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odk RCSB], [https://www.ebi.ac.uk/pdbsum/3odk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>  


===Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution===
==See Also==
 
*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
 
== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 20932746 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_20932746}}
 
==About this Structure==
3ODK is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODK OCA].
 
==Reference==
<ref group="xtra">PMID:20932746</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Large Structures]]
[[Category: Baker, L.]]
[[Category: Baker L]]
[[Category: Bryant, C J.]]
[[Category: Bryant CJ]]
[[Category: Davis, B E.]]
[[Category: Davis BE]]
[[Category: Dokurno, P.]]
[[Category: Dokurno P]]
[[Category: Fromont, C.]]
[[Category: Fromont C]]
[[Category: Matossova, N.]]
[[Category: Matossova N]]
[[Category: Moore, J D.]]
[[Category: Moore JD]]
[[Category: Murray, J B.]]
[[Category: Murray JB]]
[[Category: Northfield, C J.]]
[[Category: Northfield CJ]]
[[Category: Nunns, C.]]
[[Category: Nunns C]]
[[Category: Oldfield, V.]]
[[Category: Oldfield V]]
[[Category: Potter, A.]]
[[Category: Potter A]]
[[Category: Ray, S.]]
[[Category: Ray S]]
[[Category: Richardson, C M.]]
[[Category: Richardson CM]]
[[Category: Robinson, D.]]
[[Category: Robinson D]]
[[Category: Scrace, S F.]]
[[Category: Scrace SF]]
[[Category: Surgenor, A E.]]
[[Category: Surgenor AE]]
[[Category: Cell cycle]]
[[Category: Isomerase]]
[[Category: Nucleus]]
[[Category: Oncogenic transformation]]
[[Category: Phosphoprotein]]
[[Category: Ppiase]]
[[Category: Proline directed kinase]]
[[Category: Rotamase]]
[[Category: Sbdd]]
[[Category: Small molecule]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 11:22:08 2010''
Retrieved from "https://proteopedia.org/3odk"