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{{STRUCTURE_3otb|  PDB=3otb  |  SCENE=  }}
===Crystal structure of human tRNAHis guanylyltransferase (Thg1) - dGTP complex===
{{ABSTRACT_PUBMED_21059936}}


==Function==
==Crystal structure of human tRNAHis guanylyltransferase (Thg1) - dGTP complex==
[[http://www.uniprot.org/uniprot/THG1_HUMAN THG1_HUMAN]] Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.<ref>PMID:21059936</ref>
<StructureSection load='3otb' size='340' side='right'caption='[[3otb]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3otb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OTB FirstGlance]. <br>
[[3otb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTB OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PO:TRIPHOSPHATE'>3PO</scene>, <scene name='pdbligand=DGT:2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3otb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3otb OCA], [https://pdbe.org/3otb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3otb RCSB], [https://www.ebi.ac.uk/pdbsum/3otb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3otb ProSAT]</span></td></tr>
<ref group="xtra">PMID:021059936</ref><references group="xtra"/><references/>
</table>
[[Category: Mycta]]
== Function ==
[[Category: Doublie, S.]]
[https://www.uniprot.org/uniprot/THG1_HUMAN THG1_HUMAN] Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.<ref>PMID:21059936</ref>
[[Category: Eckenroth, B E.]]
== References ==
[[Category: Hyde, S J.]]
<references/>
[[Category: Catalytic carboxylate]]
__TOC__
[[Category: Guanylyltransferase]]
</StructureSection>
[[Category: Polymerase-like palm domain]]
[[Category: Homo sapiens]]
[[Category: Transferase]]
[[Category: Large Structures]]
[[Category: Doublie S]]
[[Category: Eckenroth BE]]
[[Category: Hyde SJ]]
Retrieved from "https://proteopedia.org/3otb"