3ox5: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry 3ox5 is ON HOLD until Paper Publication~~

==Crystal Structure of the calcium sensor calcium-binding protein 1 (CaBP1)==

~~Authors: Findeisen, F., Minor, D.L.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3ox5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OX5 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=3OX5 FirstGlance].

~~Description:~~ Crystal Structure of the calcium sensor calcium-binding protein 1 (CaBP1)

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

''~~Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 6 05~~:49:~~38 2010~~''

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=3ox5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ox5 OCA], [https://pdbe.org/3ox5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ox5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ox5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ox5 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CABP1_HUMAN CABP1_HUMAN] Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity).<ref>PMID:11865310</ref> <ref>PMID:14570872</ref> <ref>PMID:15140941</ref> <ref>PMID:15980432</ref> <ref>PMID:15895247</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Findeisen F]]

[[Category: Minor DL]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 3ox5 is ON HOLD  until Paper Publication
+==Crystal Structure of the calcium sensor calcium-binding protein 1 (CaBP1)==
+<StructureSection load='3ox5' size='340' side='right'caption='[[3ox5]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors: Findeisen, F., Minor, D.L.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ox5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OX5 FirstGlance]. <br>
-Description: Crystal Structure of the calcium sensor calcium-binding protein 1 (CaBP1)
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  6 05:49:38 2010''
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ox5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ox5 OCA], [https://pdbe.org/3ox5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ox5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ox5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ox5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CABP1_HUMAN CABP1_HUMAN] Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity).<ref>PMID:11865310</ref> <ref>PMID:14570872</ref> <ref>PMID:15140941</ref> <ref>PMID:15980432</ref> <ref>PMID:15895247</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Findeisen F]]
+[[Category: Minor DL]]