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[[Image:3pok.png|left|200px]]


{{STRUCTURE_3pok|  PDB=3pok  |  SCENE=  }}
==Interleukin-1-beta LBT L3 Mutant==
 
<StructureSection load='3pok' size='340' side='right'caption='[[3pok]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===Interleukin-1-beta LBT L3 Mutant===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3pok]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3POK FirstGlance]. <br>
{{ABSTRACT_PUBMED_21182275}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pok OCA], [https://pdbe.org/3pok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pok RCSB], [https://www.ebi.ac.uk/pdbsum/3pok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pok ProSAT]</span></td></tr>
==About this Structure==
</table>
[[3pok]] is a 1 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POK OCA].  
== Function ==
[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>


==See Also==
==See Also==
*[[Interleukin|Interleukin]]
*[[Interleukin 3D structures|Interleukin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021182275</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Allen, K N.]]
[[Category: Large Structures]]
[[Category: Barthelmes, K.]]
[[Category: Allen KN]]
[[Category: DeNunzio, N J.]]
[[Category: Barthelmes K]]
[[Category: Imperiali, B.]]
[[Category: DeNunzio NJ]]
[[Category: Jonker, H R.A.]]
[[Category: Imperiali B]]
[[Category: Peisach, E.]]
[[Category: Jonker HRA]]
[[Category: Reynolds, A M.]]
[[Category: Peisach E]]
[[Category: Schwalbe, H.]]
[[Category: Reynolds AM]]
[[Category: Beta trefoil]]
[[Category: Schwalbe H]]
[[Category: Cytokine]]
[[Category: Extracellular membrane]]
[[Category: Interleukin]]
[[Category: Lanthanide tag]]
[[Category: Receptor]]
[[Category: Signaling]]