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{{STRUCTURE_3pp2|  PDB=3pp2  |  SCENE=  }}
===Crystal structure of the pleckstrin homology domain of ArhGAP27===


==Function==
==Crystal structure of the pleckstrin homology domain of ArhGAP27==
[[http://www.uniprot.org/uniprot/RHG27_HUMAN RHG27_HUMAN]] Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).  
<StructureSection load='3pp2' size='340' side='right'caption='[[3pp2]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3pp2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PP2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.421&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pp2 OCA], [https://pdbe.org/3pp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pp2 RCSB], [https://www.ebi.ac.uk/pdbsum/3pp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pp2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHG27_HUMAN RHG27_HUMAN] Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).


==About this Structure==
==See Also==
[[3pp2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PP2 OCA].
*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Edwards, A M.]]
[[Category: Bountra C]]
[[Category: Li, Y.]]
[[Category: Edwards AM]]
[[Category: Nedyalkova, L.]]
[[Category: Li Y]]
[[Category: Park, H.]]
[[Category: Nedyalkova L]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Park H]]
[[Category: Shen, L.]]
[[Category: Shen L]]
[[Category: Tempel, W.]]
[[Category: Tempel W]]
[[Category: Tong, Y.]]
[[Category: Tong Y]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Wernimont, A K.]]
[[Category: Wernimont AK]]
[[Category: Gtpase activator]]
[[Category: Hydrolase activator]]
[[Category: Ph domain]]
[[Category: Pleckstrin homology domain]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
Retrieved from "https://proteopedia.org/3pp2"