3puh: Difference between revisions
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== | ==Cocaine Esterase, wild-type biologically active dimer== | ||
[[3puh]] is a 2 chain structure with sequence from [ | <StructureSection load='3puh' size='340' side='right'caption='[[3puh]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3puh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._MB1_'Bresler_1999' Rhodococcus sp. MB1 'Bresler 1999']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PUH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3puh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3puh OCA], [https://pdbe.org/3puh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3puh RCSB], [https://www.ebi.ac.uk/pdbsum/3puh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3puh ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref> | |||
==See Also== | ==See Also== | ||
*[[Cocaine esterase|Cocaine esterase]] | *[[Cocaine esterase|Cocaine esterase]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rhodococcus sp. MB1 'Bresler 1999']] | ||
[[Category: | [[Category: Nance MR]] | ||
[[Category: Tesmer JJG]] | |||
Latest revision as of 10:43, 21 February 2024
Cocaine Esterase, wild-type biologically active dimer
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