3ru0: Difference between revisions

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[[Image:3ru0.jpg|left|200px]]


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==Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound==
The line below this paragraph, containing "STRUCTURE_3ru0", creates the "Structure Box" on the page.
<StructureSection load='3ru0' size='340' side='right'caption='[[3ru0]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ru0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RU0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.849&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3ru0|  PDB=3ru0  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ru0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ru0 OCA], [https://pdbe.org/3ru0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ru0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ru0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ru0 ProSAT]</span></td></tr>
 
</table>
===Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound===
== Function ==
 
[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref>
 
== References ==
==About this Structure==
<references/>
[[3ru0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RU0 OCA].  
__TOC__
[[Category: Histone-lysine N-methyltransferase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arnold, L.]]
[[Category: Large Structures]]
[[Category: Brown, M.]]
[[Category: Arnold L]]
[[Category: Crew, A.]]
[[Category: Brown M]]
[[Category: Das, C.]]
[[Category: Crew A]]
[[Category: Emtage, S.]]
[[Category: Das C]]
[[Category: Foreman, K W.]]
[[Category: Emtage S]]
[[Category: Harriss, J.]]
[[Category: Foreman KW]]
[[Category: Park, F.]]
[[Category: Harriss J]]
[[Category: Shaaban, S.]]
[[Category: Park F]]
[[Category: Tucker, P.]]
[[Category: Shaaban S]]
[[Category: Zhu, L.]]
[[Category: Tucker P]]
[[Category: Zhu L]]
Retrieved from "https://proteopedia.org/3ru0"