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==Crystal structure of the R-M controller protein C.Esp1396I OL operator complex==
==Crystal structure of the R-M controller protein C.Esp1396I OL operator complex==
<StructureSection load='3s8q' size='340' side='right' caption='[[3s8q]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3s8q' size='340' side='right'caption='[[3s8q]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3s8q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_sp._rfl1396 Enterobacter sp. rfl1396]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S8Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[3s8q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacter_sp._RFL1396 Enterobacter sp. RFL1396]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8Q FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3clc|3clc]], [[3g5g|3g5g]], [[3fya|3fya]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">esp1396IC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=211595 Enterobacter sp. RFL1396])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8q OCA], [https://pdbe.org/3s8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8q RCSB], [https://www.ebi.ac.uk/pdbsum/3s8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8q ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s8q RCSB], [http://www.ebi.ac.uk/pdbsum/3s8q PDBsum]</span></td></tr>
</table>
<table>
== Function ==
<div style="background-color:#fffaf0;">
[https://www.uniprot.org/uniprot/Q8GGH0_9ENTR Q8GGH0_9ENTR]
== Publication Abstract from PubMed ==
The controller protein C.Esp1396I regulates the timing of gene expression of the restriction-modification (RM) genes of the RM system Esp1396I. The molecular recognition of promoter sequences by such transcriptional regulators is poorly understood, in part because the DNA sequence motifs do not conform to a well-defined symmetry. We report here the crystal structure of the controller protein bound to a DNA operator site. The structure reveals how two different symmetries within the operator are simultaneously recognized by the homo-dimeric protein, underpinned by a conformational change in one of the protein subunits. The recognition of two different DNA symmetries through movement of a flexible loop in one of the protein subunits may represent a general mechanism for the recognition of pseudo-symmetric DNA sequences.
 
Recognition of dual symmetry by the controller protein C.Esp1396I based on the structure of the transcriptional activation complex.,McGeehan JE, Ball NJ, Streeter SD, Thresh SJ, Kneale GG Nucleic Acids Res. 2011 Dec 30. PMID:22210861<ref>PMID:22210861</ref>
 
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Enterobacter sp. rfl1396]]
[[Category: Enterobacter sp. RFL1396]]
[[Category: Ball, N J.]]
[[Category: Large Structures]]
[[Category: Kneale, G G.]]
[[Category: Ball NJ]]
[[Category: McGeehan, J E.]]
[[Category: Kneale GG]]
[[Category: Streeter, S D.]]
[[Category: McGeehan JE]]
[[Category: Thresh, S J.]]
[[Category: Streeter SD]]
[[Category: Dna-binding protein]]
[[Category: Thresh S-J]]
[[Category: Helix-turn-helix]]
[[Category: Protein binding-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Transcriptional regulator]]
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