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[[Image:437d.gif|left|200px]]


{{Structure
==CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING==
|PDB= 437d |SIZE=350|CAPTION= <scene name='initialview01'>437d</scene>, resolution 1.6&Aring;
<StructureSection load='437d' size='340' side='right'caption='[[437d]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
<table><tr><td colspan='2'>[[437d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=437D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=437D FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=437d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=437d OCA], [https://pdbe.org/437d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=437d RCSB], [https://www.ebi.ac.uk/pdbsum/437d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=437d ProSAT]</span></td></tr>
 
</table>
'''CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING'''
__TOC__
 
</StructureSection>
 
[[Category: Large Structures]]
==Overview==
[[Category: Berger JM]]
Many viruses regulate translation of polycistronic mRNA using a -1 ribosomal frameshift induced by an RNA pseudoknot. A pseudoknot has two stems that form a quasi-continuous helix and two connecting loops. A 1.6 A crystal structure of the beet western yellow virus (BWYV) pseudoknot reveals rotation and a bend at the junction of the two stems. A loop base is inserted in the major groove of one stem with quadruple-base interactions. The second loop forms a new minor-groove triplex motif with the other stem, involving 2'-OH and triple-base interactions, as well as sodium ion coordination. Overall, the number of hydrogen bonds stabilizing the tertiary interactions exceeds the number involved in Watson-Crick base pairs. This structure will aid mechanistic analyses of ribosomal frameshifting.
[[Category: Chen L]]
 
[[Category: Egli M]]
==About this Structure==
[[Category: Rich A]]
437D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=437D OCA].  
[[Category: Su L]]
 
==Reference==
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot., Su L, Chen L, Egli M, Berger JM, Rich A, Nat Struct Biol. 1999 Mar;6(3):285-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10074948 10074948]
[[Category: Protein complex]]
[[Category: Berger, J M.]]
[[Category: Chen, L.]]
[[Category: Egli, M.]]
[[Category: Rich, A.]]
[[Category: Su, L.]]
[[Category: MG]]
[[Category: NA]]
[[Category: pseudoknot]]
[[Category: rna]]
[[Category: triplex]]
[[Category: viral frameshifting]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:08:15 2008''
Retrieved from "https://proteopedia.org/437d"