4ddm: Difference between revisions

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{{STRUCTURE_4ddm|  PDB=4ddm  |  SCENE=  }}
===Pantothenate synthetase in complex with 2,1,3-benzothiadiazole-5-carboxylic acid===
{{ABSTRACT_PUBMED_23872845}}


==Function==
==Pantothenate synthetase in complex with 2,1,3-benzothiadiazole-5-carboxylic acid==
[[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>
<StructureSection load='4ddm' size='340' side='right'caption='[[4ddm]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ddm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DDM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HO:2,1,3-BENZOTHIADIAZOLE-5-CARBOXYLIC+ACID'>0HO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ddm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ddm OCA], [https://pdbe.org/4ddm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ddm RCSB], [https://www.ebi.ac.uk/pdbsum/4ddm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ddm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>  


==About this Structure==
==See Also==
[[4ddm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DDM OCA].
*[[Pantothenate synthetase|Pantothenate synthetase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:023872845</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Pantoate--beta-alanine ligase]]
[[Category: Silvestre HL]]
[[Category: Silvestre, H L.]]
[[Category: Alpha beta/adenine nucleotide alpha hydrolase-like]]
[[Category: Fragment-based drug discovery]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Pantoate and b-ala binding]]

Latest revision as of 10:44, 1 March 2024

Pantothenate synthetase in complex with 2,1,3-benzothiadiazole-5-carboxylic acid

4ddm, resolution 1.83Å

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