4eox: Difference between revisions
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==X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor== | |||
<StructureSection load='4eox' size='340' side='right'caption='[[4eox]], [[Resolution|resolution]] 1.78Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4eox]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.783Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0S5:N-BENZOYL-1-[(2R)-3-CYCLOPENTYL-2-{[FORMYL(HYDROXY)AMINO]METHYL}PROPANOYL]-L-PROLINAMIDE'>0S5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eox OCA], [https://pdbe.org/4eox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eox RCSB], [https://www.ebi.ac.uk/pdbsum/4eox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eox ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DEF_STRR6 DEF_STRR6] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptococcus pneumoniae R6]] | |||
[[Category: Campobasso N]] | |||
[[Category: Ward P]] | |||
Latest revision as of 11:04, 1 March 2024
X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor
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