4fxe: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:4fxe.jpg|left|200px]]


{{STRUCTURE_4fxe|  PDB=4fxe  |  SCENE=  }}
==Crystal structure of the intact E. coli RelBE toxin-antitoxin complex==
 
<StructureSection load='4fxe' size='340' side='right'caption='[[4fxe]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
===Crystal structure of the intact E. coli RelBE toxin-antitoxin complex===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4fxe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FXE FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7503&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[4fxe]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXE OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxe OCA], [https://pdbe.org/4fxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fxe RCSB], [https://www.ebi.ac.uk/pdbsum/4fxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxe ProSAT]</span></td></tr>
[[Category: Escherichia coli]]
</table>
[[Category: Boggild, A.]]
== Function ==
[[Category: Brodersen, D E.]]
[https://www.uniprot.org/uniprot/RELB_ECOLI RELB_ECOLI] Antitoxin component of a toxin-antitoxin (TA) module. Counteracts the effect of RelE via direct protein-protein interaction, enabling the reversion of translation inhibition. Also acts as an autorepressor of relBE transcription. DNA-binding and repression is stronger when complexed with corepressor RelE. Increased transcription rate of relBE and activation of relE is consistent with a lower level of RelB in starved cells due to degradation of RelB by protease Lon.<ref>PMID:9767574</ref> <ref>PMID:11274135</ref> <ref>PMID:11717402</ref> <ref>PMID:12123459</ref> <ref>PMID:19707553</ref>  Seems to be a principal mediator of cell death in liquid media.<ref>PMID:9767574</ref> <ref>PMID:11274135</ref> <ref>PMID:11717402</ref> <ref>PMID:12123459</ref> <ref>PMID:19707553</ref>
[[Category: Sofos, N.]]
== References ==
[[Category: Nuclease]]
<references/>
[[Category: Relb]]
__TOC__
[[Category: Rele]]
</StructureSection>
[[Category: Ribosome]]
[[Category: Escherichia coli K-12]]
[[Category: Stress response]]
[[Category: Large Structures]]
[[Category: Toxin]]
[[Category: Boggild A]]
[[Category: Toxin-toxin inhibitor complex]]
[[Category: Brodersen DE]]
[[Category: Toxin/antitoxin system]]
[[Category: Sofos N]]
[[Category: Translational control]]

Latest revision as of 11:23, 1 March 2024

Crystal structure of the intact E. coli RelBE toxin-antitoxin complex

4fxe, resolution 2.75Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=4fxe&oldid=4073641"