4g3d: Difference between revisions

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[[Image:4g3d.png|left|200px]]


{{STRUCTURE_4g3d|  PDB=4g3d  |  SCENE=  }}
==Crystal structure of human NF-kappaB inducing kinase (NIK)==
 
<StructureSection load='4g3d' size='340' side='right'caption='[[4g3d]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
===Crystal structure of human NF-kappaB inducing kinase (NIK)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4g3d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3D FirstGlance]. <br>
{{ABSTRACT_PUBMED_22921830}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3d OCA], [https://pdbe.org/4g3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3d RCSB], [https://www.ebi.ac.uk/pdbsum/4g3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3d ProSAT]</span></td></tr>
[[4g3d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3D OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/M3K14_HUMAN M3K14_HUMAN] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:15084608</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mitogen-activated protein kinase kinase kinase]]
[[Category: Large Structures]]
[[Category: G., de Leon-Boenig.]]
[[Category: Hymowitz SG]]
[[Category: Hymowitz, S G.]]
[[Category: De Leon-Boenig G]]
[[Category: Map3k14]]
[[Category: Nf-kappab]]
[[Category: Non-rd kinase]]
[[Category: Protein serine/threonine kinase]]
[[Category: Transferase]]
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