4hvy: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4hvy is ~~ON HOLD until Paper Publication~~

==A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration==

~~Authors~~: ~~Asial~~, I., ~~Cheng~~, Y.X., ~~Engman~~, H., Wu, B., ~~Dollhopf~~, M., ~~Nordlund~~, P., Cornvik, T.

== Structural highlights ==

<table><tr><td colspan='2'>[[4hvy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVY OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4HVY FirstGlance].

~~Description~~: ~~A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4hvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hvy OCA], [https://pdbe.org/4hvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hvy RCSB], [https://www.ebi.ac.uk/pdbsum/4hvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hvy ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/NUD18_HUMAN NUD18_HUMAN] Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Asial I]]

[[Category: Cheng YX]]

[[Category: Cornvik T]]

[[Category: Dollhopf M]]

[[Category: Engman H]]

[[Category: Nordlund P]]

[[Category: Wu B]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4hvy is ON HOLD  until Paper Publication
+==A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration==
+<StructureSection load='4hvy' size='340' side='right'caption='[[4hvy]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
-Authors: Asial, I., Cheng, Y.X., Engman, H., Wu, B., Dollhopf, M., Nordlund, P., Cornvik, T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4hvy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HVY FirstGlance]. <br>
-Description: A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hvy OCA], [https://pdbe.org/4hvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hvy RCSB], [https://www.ebi.ac.uk/pdbsum/4hvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hvy ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NUD18_HUMAN NUD18_HUMAN] Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Asial I]]
+[[Category: Cheng YX]]
+[[Category: Cornvik T]]
+[[Category: Dollhopf M]]
+[[Category: Engman H]]
+[[Category: Nordlund P]]
+[[Category: Wu B]]