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{{Large structure}}
{{STRUCTURE_4jkr|  PDB=4jkr  |  SCENE=  }}
===Crystal Structure of E. coli RNA Polymerase in complex with ppGpp===
{{ABSTRACT_PUBMED_23623685}}


==Function==
==Crystal Structure of E. coli RNA Polymerase in complex with ppGpp==
[[http://www.uniprot.org/uniprot/C9QUL2_ECOD1 C9QUL2_ECOD1]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).[HAMAP-Rule:MF_00366][SAAS:SAAS012293_004_017283] [[http://www.uniprot.org/uniprot/C5A0S8_ECOBW C5A0S8_ECOBW]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity).[SAAS:SAAS012754_004_011999] [[http://www.uniprot.org/uniprot/C9QV90_ECOD1 C9QV90_ECOD1]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity).[HAMAP-Rule:MF_01321][RuleBase:RU000432] [[http://www.uniprot.org/uniprot/RPOD_ECOLI RPOD_ECOLI]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This is the primary sigma factor of this bacterium.
<StructureSection load='4jkr' size='340' side='right'caption='[[4jkr]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jkr]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BW2952 Escherichia coli BW2952], [https://en.wikipedia.org/wiki/Escherichia_coli_DH1 Escherichia coli DH1], [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Escherichia_coli_O104:H4_str._2009EL-2071 Escherichia coli O104:H4 str. 2009EL-2071]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JKR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G4P:GUANOSINE-5,3-TETRAPHOSPHATE'>G4P</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jkr OCA], [https://pdbe.org/4jkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jkr RCSB], [https://www.ebi.ac.uk/pdbsum/4jkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jkr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0E0Y7A2_ECO1C A0A0E0Y7A2_ECO1C] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321][RuleBase:RU363031]


==About this Structure==
==See Also==
[[4jkr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_bw2952 Escherichia coli bw2952], [http://en.wikipedia.org/wiki/Escherichia_coli_dh1 Escherichia coli dh1], [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12] and [http://en.wikipedia.org/wiki/Escherichia_coli_o104:h4_str._2009el-2071 Escherichia coli o104:h4 str. 2009el-2071]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKR OCA].
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
 
*[[Sigma factor 3D structures|Sigma factor 3D structures]]
==Reference==
__TOC__
<ref group="xtra">PMID:023623685</ref><references group="xtra"/><references/>
</StructureSection>
[[Category: DNA-directed RNA polymerase]]
[[Category: Escherichia coli BW2952]]
[[Category: Escherichia coli bw2952]]
[[Category: Escherichia coli DH1]]
[[Category: Escherichia coli dh1]]
[[Category: Escherichia coli K-12]]
[[Category: Escherichia coli k-12]]
[[Category: Escherichia coli O104:H4 str. 2009EL-2071]]
[[Category: Escherichia coli o104:h4 str. 2009el-2071]]
[[Category: Large Structures]]
[[Category: Steitz, T A.]]
[[Category: Steitz TA]]
[[Category: Wang, Y.]]
[[Category: Wang Y]]
[[Category: Zuo, Y.]]
[[Category: Zuo Y]]
[[Category: Rna polymerase]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4jkr"