4kiw: Difference between revisions

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'''Unreleased structure'''


The entry 4kiw is ON HOLD  until Paper Publication
==Design and structural analysis of aromatic inhibitors of type II dehydroquinate dehydratase from Mycobacterium tuberculosis - compound 49e [5-[(3-nitrobenzyl)amino]benzene-1,3-dicarboxylic acid]==
<StructureSection load='4kiw' size='340' side='right'caption='[[4kiw]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4kiw]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KIW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KIW:5-[(3-NITROBENZYL)AMINO]BENZENE-1,3-DICARBOXYLIC+ACID'>KIW</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kiw OCA], [https://pdbe.org/4kiw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kiw RCSB], [https://www.ebi.ac.uk/pdbsum/4kiw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kiw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]


Authors: Dias, M.V.B, Howard, N.G., Blundell, T.L., Abell, C.
==See Also==
 
*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
Description: Design and structural analysis of aromatic inhibitors of type II dehydroquinate dehydratase from Mycobacterium tuberculosis -compound 49e [5-[(3-nitrobenzyl)amino]benzene-1,3-dicarboxylic acid]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Abell C]]
[[Category: Blundell TL]]
[[Category: Dias MVB]]
[[Category: Howard NG]]
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