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{{STRUCTURE_4kl9|  PDB=4kl9  |  SCENE=  }}
===Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in the space group C2===
{{ABSTRACT_PUBMED_24210757}}


==Function==
==Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in the space group C2==
[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.  
<StructureSection load='4kl9' size='340' side='right'caption='[[4kl9]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4kl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KL9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kl9 OCA], [https://pdbe.org/4kl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kl9 RCSB], [https://www.ebi.ac.uk/pdbsum/4kl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kl9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.


==About this Structure==
==See Also==
[[4kl9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KL9 OCA].
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:024210757</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Dihydrofolate reductase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Blundell, T L.]]
[[Category: Blundell TL]]
[[Category: Dias, M V.B]]
[[Category: Dias MVB]]
[[Category: Tyrakis, P.]]
[[Category: Tyrakis P]]
[[Category: Oxidoreductase]]
[[Category: Reductase]]
Retrieved from "https://proteopedia.org/4kl9"