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{{STRUCTURE_4nsc|  PDB=4nsc  |  SCENE=  }}
===Crystal Structure of CBARA1 in the Apo-form===
{{ABSTRACT_PUBMED_24514027}}


==Function==
==Crystal Structure of CBARA1 in the Apo-form==
[[http://www.uniprot.org/uniprot/MICU1_HUMAN MICU1_HUMAN]] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. Acts as a gatekeeper that senses calcium level via its EF-hand domains and sets a threshold for mitochondrial calcium uptake by MCU, thereby preventing mitochondrial calcium overload. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.<ref>PMID:16002733</ref> <ref>PMID:20693986</ref> <ref>PMID:23101630</ref> <ref>PMID:22904319</ref>
<StructureSection load='4nsc' size='340' side='right'caption='[[4nsc]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nsc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NSC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nsc OCA], [https://pdbe.org/4nsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nsc RCSB], [https://www.ebi.ac.uk/pdbsum/4nsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nsc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MICU1_HUMAN MICU1_HUMAN] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. Acts as a gatekeeper that senses calcium level via its EF-hand domains and sets a threshold for mitochondrial calcium uptake by MCU, thereby preventing mitochondrial calcium overload. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.<ref>PMID:16002733</ref> <ref>PMID:20693986</ref> <ref>PMID:23101630</ref> <ref>PMID:22904319</ref>  


==About this Structure==
==See Also==
[[4nsc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSC OCA].
*[[Calcium uptake protein 3D structures|Calcium uptake protein 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024514027</ref><references group="xtra"/><references/>
__TOC__
[[Category: Li, S.]]
</StructureSection>
[[Category: Shen, Y.]]
[[Category: Homo sapiens]]
[[Category: Wang, L.]]
[[Category: Large Structures]]
[[Category: Yang, X.]]
[[Category: Li S]]
[[Category: Calcium binding protein]]
[[Category: Shen Y]]
[[Category: Ef-hand]]
[[Category: Wang L]]
[[Category: Yang X]]
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