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{{STRUCTURE_4o7q|  PDB=4o7q  |  SCENE=  }}
===Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions===
{{ABSTRACT_PUBMED_24406744}}


==Function==
==Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions==
[[http://www.uniprot.org/uniprot/AIM2_HUMAN AIM2_HUMAN]] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.<ref>PMID:16432157</ref> <ref>PMID:17726700</ref> <ref>PMID:19158679</ref> <ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:20566831</ref>
<StructureSection load='4o7q' size='340' side='right'caption='[[4o7q]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4o7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O7Q FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o7q OCA], [https://pdbe.org/4o7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o7q RCSB], [https://www.ebi.ac.uk/pdbsum/4o7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o7q ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AIM2_HUMAN AIM2_HUMAN] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.<ref>PMID:16432157</ref> <ref>PMID:17726700</ref> <ref>PMID:19158679</ref> <ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:20566831</ref>  


==About this Structure==
==See Also==
[[4o7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7Q OCA].
*[[Pyrin domain|Pyrin domain]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024406744</ref><references group="xtra"/><references/>
__TOC__
[[Category: Human]]
</StructureSection>
[[Category: Kabaleeswaran, V.]]
[[Category: Homo sapiens]]
[[Category: Lu, A.]]
[[Category: Large Structures]]
[[Category: Wu, H.]]
[[Category: Kabaleeswaran V]]
[[Category: Apoptosis]]
[[Category: Lu A]]
[[Category: Inflammasome]]
[[Category: Wu H]]
[[Category: Pyd/dd]]
[[Category: Signal transduction]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/4o7q"