5he1: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5he1 is ~~ON HOLD~~

==Human GRK2 in complex with Gbetagamma subunits and CCG224062==

== Structural highlights ==

<table><tr><td colspan='2'>[[5he1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HE1 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5HE1 FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZS2:(4~{S})-4-[4-FLUORANYL-3-(ISOQUINOLIN-1-YLMETHYLCARBAMOYL)PHENYL]-~{N}-(1~{H}-INDAZOL-5-YL)-6-METHYL-2-OXIDANYLIDENE-3,4-DIHYDRO-1~{H}-PYRIMIDINE-5-CARBOXAMIDE'>ZS2</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5he1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5he1 OCA], [https://pdbe.org/5he1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5he1 RCSB], [https://www.ebi.ac.uk/pdbsum/5he1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5he1 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref>

~~Authors: Cato, M.C., Tesmer, J.J.G.~~

==See Also==

*[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]]

~~Description~~: ~~Human GRK2 in complex with Gbetagamma subunits and CCG224062~~

*[[Transducin 3D structures|Transducin 3D structures]]

[[Category: ~~Unreleased~~ Structures]]

== References ==

[[Category: Cato~~, M.C~~]]

[[Category: Tesmer~~, J.J.G~~]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Cato MC]]

[[Category: Tesmer JJG]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5he1 is ON HOLD
+==Human GRK2 in complex with Gbetagamma subunits and CCG224062==
+<StructureSection load='5he1' size='340' side='right'caption='[[5he1]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5he1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HE1 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZS2:(4~{S})-4-[4-FLUORANYL-3-(ISOQUINOLIN-1-YLMETHYLCARBAMOYL)PHENYL]-~{N}-(1~{H}-INDAZOL-5-YL)-6-METHYL-2-OXIDANYLIDENE-3,4-DIHYDRO-1~{H}-PYRIMIDINE-5-CARBOXAMIDE'>ZS2</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5he1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5he1 OCA], [https://pdbe.org/5he1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5he1 RCSB], [https://www.ebi.ac.uk/pdbsum/5he1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5he1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref>
-Authors: Cato, M.C., Tesmer, J.J.G.
+==See Also==
+*[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]]
-Description: Human GRK2 in complex with Gbetagamma subunits and CCG224062
+*[[Transducin 3D structures|Transducin 3D structures]]
-[[Category: Unreleased Structures]]
+== References ==
-[[Category: Cato, M.C]]
+<references/>
-[[Category: Tesmer, J.J.G]]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Cato MC]]
+[[Category: Tesmer JJG]]