5hjs: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5hjs is ~~ON HOLD~~

==Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease==

== Structural highlights ==

<table><tr><td colspan='2'>[[5hjs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HJS OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5HJS FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=668:2-CHLORO-4-{1-[(2R)-2-HYDROXY-3-METHYL-2-(TRIFLUOROMETHYL)BUTANOYL]-4,4-BIPIPERIDIN-1-YL}-N,N-DIMETHYLBENZAMIDE'>668</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5hjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hjs OCA], [https://pdbe.org/5hjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hjs RCSB], [https://www.ebi.ac.uk/pdbsum/5hjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hjs ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/NR1H3_HUMAN NR1H3_HUMAN] Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).

~~Authors: Gopal Parthasarathy, Daniel Klein~~

==See Also==

*[[Liver X receptor|Liver X receptor]]

~~Description~~: ~~Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease~~

__TOC__

[[Category: ~~Unreleased~~ Structures]]

</StructureSection>

[[Category: ~~Gopal~~ Parthasarathy~~, Daniel Klein~~]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Klein D]]

[[Category: Parthasarathy G]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5hjs is ON HOLD
+==Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease==
+<StructureSection load='5hjs' size='340' side='right'caption='[[5hjs]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5hjs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HJS FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=668:2-CHLORO-4-{1-[(2R)-2-HYDROXY-3-METHYL-2-(TRIFLUOROMETHYL)BUTANOYL]-4,4-BIPIPERIDIN-1-YL}-N,N-DIMETHYLBENZAMIDE'>668</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hjs OCA], [https://pdbe.org/5hjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hjs RCSB], [https://www.ebi.ac.uk/pdbsum/5hjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hjs ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NR1H3_HUMAN NR1H3_HUMAN] Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
-Authors: Gopal Parthasarathy, Daniel Klein
+==See Also==
+*[[Liver X receptor|Liver X receptor]]
-Description: Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Gopal Parthasarathy, Daniel Klein]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Klein D]]
+[[Category: Parthasarathy G]]