5l33: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l33 OCA], [https://pdbe.org/5l33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l33 RCSB], [https://www.ebi.ac.uk/pdbsum/5l33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l33 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l33 OCA], [https://pdbe.org/5l33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l33 RCSB], [https://www.ebi.ac.uk/pdbsum/5l33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l33 ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Active sites and ligand-binding cavities in native proteins are often formed by curved beta sheets, and the ability to control beta-sheet curvature would allow design of binding proteins with cavities customized to specific ligands. Toward this end, we investigated the mechanisms controlling beta-sheet curvature by studying the geometry of beta sheets in naturally occurring protein structures and folding simulations. The principles emerging from this analysis were used to design, de novo, a series of proteins with curved beta sheets topped with alpha helices. Nuclear magnetic resonance and crystal structures of the designs closely match the computational models, showing that beta-sheet curvature can be controlled with atomic-level accuracy. Our approach enables the design of proteins with cavities and provides a route to custom design ligand-binding and catalytic sites.
Principles for designing proteins with cavities formed by curved beta sheets.,Marcos E, Basanta B, Chidyausiku TM, Tang Y, Oberdorfer G, Liu G, Swapna GV, Guan R, Silva DA, Dou J, Pereira JH, Xiao R, Sankaran B, Zwart PH, Montelione GT, Baker D Science. 2017 Jan 13;355(6321):201-206. doi: 10.1126/science.aah7389. PMID:28082595<ref>PMID:28082595</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5l33" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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Latest revision as of 12:43, 6 March 2024

Crystal structure of a de novo designed protein with curved beta-sheet

5l33, resolution 2.00Å

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