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==CRYSTAL STRUCTURE OF ORANGE CAROTENOID PROTEIN==
==CRYSTAL STRUCTURE OF ORANGE CAROTENOID PROTEIN==
<StructureSection load='5ui2' size='340' side='right' caption='[[5ui2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='5ui2' size='340' side='right'caption='[[5ui2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ui2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arthrospira_maxima Arthrospira maxima]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m98 1m98]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UI2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ui2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Limnospira_maxima Limnospira maxima]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m98 1m98]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UI2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EQ3:(3R)-3-HYDROXY-BETA,BETA-CAROTEN-4-ONE'>EQ3</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ui2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ui2 OCA], [http://pdbe.org/5ui2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ui2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ui2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ui2 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EQ3:(3R)-3-HYDROXY-BETA,BETA-CAROTEN-4-ONE'>EQ3</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ui2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ui2 OCA], [https://pdbe.org/5ui2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ui2 RCSB], [https://www.ebi.ac.uk/pdbsum/5ui2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ui2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OCP_ARTMA OCP_ARTMA]] Acts as a photo-protectant. Essential for inhibiting white and blue-green light non-photochemical quenching (NPQ). Binding carotenoids improves OCP's intrinsic photoprotectant activity by broadening its absorption spectrum and facilitating the dissipation of absorbed energy.<ref>PMID:15751975</ref> 
[https://www.uniprot.org/uniprot/OCP_LIMMA OCP_LIMMA] Acts as a blue-light photoreceptor and photo-protectant. Essential for inhibiting damaged induced by excess blue-green light via a process known as non-photochemical quenching (NPQ). Binding carotenoids improves OCP's intrinsic photoprotectant activity by broadening its absorption spectrum and facilitating the dissipation of absorbed energy (PubMed:15751975). In the dark or dim light the stable inactive form (OCP-O) is orange, upon illumination with blue-green light it converts to a metastable active red form (OCP-R), inducing energy dissipation, quenching cellular fluorescence via NPQ (By similarity).[UniProtKB:P74102]<ref>PMID:15751975</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Carotenoids undergo a wide range of photochemical reactions in animal, plant, and microbial systems. In photosynthetic organisms, in addition to light harvesting, they perform an essential role in protecting against light-induced damage by quenching singlet oxygen, superoxide anion radicals, or triplet-state chlorophyll. We have determined the crystal structure of a water-soluble orange carotenoid protein (OCP) isolated from the cyanobacterium Arthrospira maxima at a resolution of 2.1 A. OCP forms a homodimer with one carotenoid molecule per monomer. The carotenoid binding site is lined by a striking number of methionine residues. The structure reveals several possible ways in which the protein environment influences the spectral properties of the pigment and provides insight into how the OCP carries out its putative functions in photoprotection.
 
The crystal structure of a cyanobacterial water-soluble carotenoid binding protein.,Kerfeld CA, Sawaya MR, Brahmandam V, Cascio D, Ho KK, Trevithick-Sutton CC, Krogmann DW, Yeates TO Structure. 2003 Jan;11(1):55-65. PMID:12517340<ref>PMID:12517340</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5ui2" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arthrospira maxima]]
[[Category: Large Structures]]
[[Category: KERFELD, C A]]
[[Category: Limnospira maxima]]
[[Category: KROGMANN, D]]
[[Category: KERFELD CA]]
[[Category: SAWAYA, M R]]
[[Category: KROGMANN D]]
[[Category: VISHNU, B]]
[[Category: SAWAYA MR]]
[[Category: YEATES, T O]]
[[Category: VISHNU B]]
[[Category: Carotenoid binding protein]]
[[Category: YEATES TO]]

Latest revision as of 14:27, 6 March 2024

CRYSTAL STRUCTURE OF ORANGE CAROTENOID PROTEIN

5ui2, resolution 2.10Å

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