6vm5: Difference between revisions
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==Structure of Moraxella osloensis Cap4 SAVED/CARF-domain containing receptor== | |||
<StructureSection load='6vm5' size='340' side='right'caption='[[6vm5]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6vm5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Moraxella_osloensis Moraxella osloensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VM5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vm5 OCA], [https://pdbe.org/6vm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vm5 RCSB], [https://www.ebi.ac.uk/pdbsum/6vm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vm5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CAP4_MOROS CAP4_MOROS] CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection (Probable). A type II-C CBASS system (PubMed:32839535).<ref>PMID:32839535</ref> <ref>PMID:32544385</ref> Probably in the presence of its endogenous cyclic nucleotide (synthesized by the cognate CD-NTase protein in the CBASS operon), or of 2',3',3'-cyclic AMP-AMP-AMP (cAAA) synthesized by Acinetobacter sp. ATCC 27244, endonucleolytically degrades dsDNA in a non-sequence specific manner. It is not activated by other cyclic nucleotides.<ref>PMID:32544385</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Moraxella osloensis]] | |||
[[Category: Antine SP]] | |||
[[Category: Cabrera V]] | |||
[[Category: Keszei AFA]] | |||
[[Category: Kranzusch PJ]] | |||
[[Category: Lee ASY]] | |||
[[Category: Lowey B]] | |||
[[Category: Mekalanos JJ]] | |||
[[Category: Morehouse BR]] | |||
[[Category: Schwede F]] | |||
[[Category: Shao S]] | |||
[[Category: Whiteley AT]] | |||
Latest revision as of 14:38, 6 March 2024
Structure of Moraxella osloensis Cap4 SAVED/CARF-domain containing receptor
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