1m2g: Difference between revisions

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[[Image:1m2g.png|left|200px]]


{{STRUCTURE_1m2g|  PDB=1m2g  |  SCENE=  }}
==Sir2 homologue-ADP ribose complex==
 
<StructureSection load='1m2g' size='340' side='right'caption='[[1m2g]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===Sir2 homologue-ADP ribose complex===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1m2g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2G FirstGlance]. <br>
{{ABSTRACT_PUBMED_12091395}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2g OCA], [https://pdbe.org/1m2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2g RCSB], [https://www.ebi.ac.uk/pdbsum/1m2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2g ProSAT]</span></td></tr>
[[1m2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2G OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/NPD1_ARCFU NPD1_ARCFU] NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription (By similarity).<ref>PMID:10841563</ref>  
<ref group="xtra">PMID:012091395</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/1m2g_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m2g ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
[[Category: Chang, J.]]
[[Category: Large Structures]]
[[Category: Cho, Y.]]
[[Category: Chang J]]
[[Category: Gene regulation]]
[[Category: Cho Y]]
[[Category: Protein-ligand complex]]
Retrieved from "https://proteopedia.org/1m2g"