1x2j: Difference between revisions

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{{Seed}}
[[Image:1x2j.png|left|200px]]


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==Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2==
The line below this paragraph, containing "STRUCTURE_1x2j", creates the "Structure Box" on the page.
<StructureSection load='1x2j' size='340' side='right'caption='[[1x2j]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1x2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X2J FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1x2j| PDB=1x2j |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x2j OCA], [https://pdbe.org/1x2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x2j RCSB], [https://www.ebi.ac.uk/pdbsum/1x2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x2j ProSAT], [https://www.topsan.org/Proteins/RSGI/1x2j TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/1x2j_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x2j ConSurf].
<div style="clear:both"></div>


===Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2===
==See Also==
 
*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_16507366}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 16507366 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_16507366}}
 
==About this Structure==
1X2J is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X2J OCA].
 
==Reference==
<ref group="xtra">PMID:16507366</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Kang, M I.]]
[[Category: Kang M-I]]
[[Category: Kobayashi, A.]]
[[Category: Kobayashi A]]
[[Category: Nakamura, Y.]]
[[Category: Nakamura Y]]
[[Category: Ohta, T.]]
[[Category: Ohta T]]
[[Category: Ohtsuji, M.]]
[[Category: Ohtsuji M]]
[[Category: Padmanabhan, B.]]
[[Category: Padmanabhan B]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Scharlock M]]
[[Category: Scharlock, M.]]
[[Category: Tong KI]]
[[Category: Tong, K I.]]
[[Category: Yamamoto M]]
[[Category: Yamamoto, M.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Beta propeller]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:13:56 2009''
Retrieved from "https://proteopedia.org/1x2j"