2cuz: Difference between revisions

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[[Image:2cuz.png|left|200px]]


{{STRUCTURE_2cuz|  PDB=2cuz  |  SCENE=  }}
==Glutamyl-tRNA synthetase from Thermus thermophilus in complex with L-glutamate==
 
<StructureSection load='2cuz' size='340' side='right'caption='[[2cuz]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
===Glutamyl-tRNA synthetase from Thermus thermophilus in complex with L-glutamate===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2cuz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUZ FirstGlance]. <br>
{{ABSTRACT_PUBMED_17161369}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cuz OCA], [https://pdbe.org/2cuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cuz RCSB], [https://www.ebi.ac.uk/pdbsum/2cuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cuz ProSAT], [https://www.topsan.org/Proteins/RSGI/2cuz TOPSAN]</span></td></tr>
[[2cuz]] is a 1 chain structure of [[Aminoacyl tRNA Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUZ OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYE_THET8 SYE_THET8] Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).<ref>PMID:11224561</ref> <ref>PMID:17161369</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cuz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cuz ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:017161369</ref><references group="xtra"/>
__TOC__
[[Category: Glutamate--tRNA ligase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Sekine S]]
[[Category: Sekine, S.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Ligase]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/2cuz"