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[[Image:2dcn.gif|left|200px]]<br /><applet load="2dcn" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2dcn, resolution 2.25&Aring;" />
'''Crystal structure of 2-keto-3-deoxygluconate kinase from Sulfolobus tokodaii complexed with 2-keto-6-phosphogluconate (alpha-furanose form)'''<br />


==About this Structure==
==Crystal structure of 2-keto-3-deoxygluconate kinase from Sulfolobus tokodaii complexed with 2-keto-6-phosphogluconate (alpha-furanose form)==
2DCN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=CKP:'>CKP</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DCN OCA].  
<StructureSection load='2dcn' size='340' side='right'caption='[[2dcn]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
[[Category: Single protein]]
== Structural highlights ==
[[Category: Sulfolobus tokodaii]]
<table><tr><td colspan='2'>[[2dcn]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii_str._7 Sulfurisphaera tokodaii str. 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DCN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DCN FirstGlance]. <br>
[[Category: Kuramitsu, S.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
[[Category: Masui, R.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CKP:(2R,3R,4S,5R)-2,3,4-TRIHYDROXY-5-[(PHOSPHONATOOXY)METHYL]TETRAHYDROFURAN-2-CARBOXYLIC+ACID'>CKP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Okazaki, S.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dcn OCA], [https://pdbe.org/2dcn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dcn RCSB], [https://www.ebi.ac.uk/pdbsum/2dcn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dcn ProSAT]</span></td></tr>
[[Category: Onda, H.]]
</table>
[[Category: Suzuki, A.]]
== Function ==
[[Category: Yamane, T.]]
[https://www.uniprot.org/uniprot/KDGK_SULTO KDGK_SULTO] Involved in the degradation of glucose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). Can also use GTP, but not ADP or AMP, as a phosphoryl donor and 2-keto-D-gluconate (KG) as a phosphoryl acceptor.<ref>PMID:17407821</ref>
[[Category: ADP]]
== Evolutionary Conservation ==
[[Category: CKP]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: K]]
Check<jmol>
[[Category: MG]]
  <jmolCheckbox>
[[Category: 2-keto-3-deoxygluconate kinase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/2dcn_consurf.spt"</scriptWhenChecked>
[[Category: 2-keto-d-gluconate]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: sulfolobus tokodaii]]
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:57:27 2008''
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dcn ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sulfurisphaera tokodaii str. 7]]
[[Category: Kuramitsu S]]
[[Category: Masui R]]
[[Category: Okazaki S]]
[[Category: Onda H]]
[[Category: Suzuki A]]
[[Category: Yamane T]]
Retrieved from "https://proteopedia.org/2dcn"