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==Structural basis for prokaryotic calcium-mediated regulation by a Streptomyces coelicolor calcium-binding protein==
==Structural basis for prokaryotic calcium-mediated regulation by a Streptomyces coelicolor calcium-binding protein==
<StructureSection load='3aka' size='340' side='right' caption='[[3aka]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3aka' size='340' side='right'caption='[[3aka]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3aka]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AKA FirstGlance]. <br>
<table><tr><td colspan='2'>[[3aka]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AKA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3akb|3akb]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cabd, SC6F11.09, SCO4411 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=100226 STRCO])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aka OCA], [https://pdbe.org/3aka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aka RCSB], [https://www.ebi.ac.uk/pdbsum/3aka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aka ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aka OCA], [http://pdbe.org/3aka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3aka RCSB], [http://www.ebi.ac.uk/pdbsum/3aka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3aka ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q9F377_STRCO Q9F377_STRCO]
The important and diverse regulatory roles of Ca(2+) in eukaryotes are conveyed by the EF-hand containing calmodulin superfamily. However, the calcium-regulatory proteins in prokaryotes are still poorly understood. In this study, we report the three-dimensional structure of the calcium-binding protein from Streptomyces coelicolor, named CabD, which shares low sequence homology with other known helix-loop-helix EF-hand proteins. The CabD structure should provide insights into the biological role of the prokaryotic calcium-binding proteins. The unusual structural features of CabD compared with prokaryotic EF-hand proteins and eukaryotic sarcoplasmic calcium-binding proteins, including the bending conformation of the first C-terminal alpha-helix, unpaired ligand-binding EF-hands and the lack of the extreme C-terminal loop region, suggest it may have a distinct and significant function in calcium-mediated bacterial physiological processes, and provide a structural basis for potential calcium-mediated regulatory roles in prokaryotes.
 
Structural basis for prokaryotic calcium-mediated regulation by a Streptomyces coelicolor calcium binding protein.,Zhao X, Pang H, Wang S, Zhou W, Yang K, Bartlam M Protein Cell. 2010 Aug;1(8):771-9. Epub 2010 Aug 28. PMID:21203918<ref>PMID:21203918</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3aka" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Strco]]
[[Category: Large Structures]]
[[Category: Bartlam, M]]
[[Category: Bartlam M]]
[[Category: Pang, H]]
[[Category: Pang H]]
[[Category: Wang, S]]
[[Category: Wang S]]
[[Category: Yang, K]]
[[Category: Yang K]]
[[Category: Zhao, X]]
[[Category: Zhao X]]
[[Category: Zhou, W]]
[[Category: Zhou W]]
[[Category: Calcium-binding protein]]
[[Category: Ef-hand]]
[[Category: Metal binding protein]]
Retrieved from "https://proteopedia.org/3aka"