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==Apo structure of the mitochondrial calcium uniporter protein MICU2==
==Apo structure of the mitochondrial calcium uniporter protein MICU2==
<StructureSection load='6eaz' size='340' side='right' caption='[[6eaz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='6eaz' size='340' side='right'caption='[[6eaz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6eaz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EAZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[6eaz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EAZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eaz OCA], [http://pdbe.org/6eaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eaz RCSB], [http://www.ebi.ac.uk/pdbsum/6eaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eaz ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eaz OCA], [https://pdbe.org/6eaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eaz RCSB], [https://www.ebi.ac.uk/pdbsum/6eaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eaz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MICU2_MOUSE MICU2_MOUSE]] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:23409044, PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering (PubMed:24560927).<ref>PMID:23409044</ref> <ref>PMID:24560927</ref>
[https://www.uniprot.org/uniprot/MICU2_MOUSE MICU2_MOUSE] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:23409044, PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering (PubMed:24560927).<ref>PMID:23409044</ref> <ref>PMID:24560927</ref>  
 
==See Also==
*[[Calcium uptake protein 3D structures|Calcium uptake protein 3D structures]]
*[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Grabarek, Z]]
[[Category: Large Structures]]
[[Category: Kamer, K J]]
[[Category: Mus musculus]]
[[Category: Calcium]]
[[Category: Grabarek Z]]
[[Category: Channel]]
[[Category: Kamer KJ]]
[[Category: Ef hand]]
[[Category: Metal binding protein]]
[[Category: Mitochondria]]
[[Category: Uniporter]]
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