3ro4: Difference between revisions
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==X-ray Structure of Ketohexokinase in complex with an indazole compound derivative== | |||
<StructureSection load='3ro4' size='340' side='right'caption='[[3ro4]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3ro4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RO4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LJ9:3-ETHYL-6-[(3AR,6AS)-HEXAHYDROPYRROLO[3,4-C]PYRROL-2(1H)-YL]-1-PHENYL-1H-INDAZOLE'>LJ9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ro4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro4 OCA], [https://pdbe.org/3ro4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ro4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ro4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ro4 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:[https://omim.org/entry/229800 229800]. Benign defect of intermediary metabolism.<ref>PMID:19237742</ref> <ref>PMID:7833921</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN] | |||
==See Also== | |||
*[[Ketohexokinase|Ketohexokinase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Abad MC]] | |||
[[Category: Gibbs AC]] | |||
Latest revision as of 12:31, 14 March 2024
X-ray Structure of Ketohexokinase in complex with an indazole compound derivative
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