3rou: Difference between revisions
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==Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)== | |||
<StructureSection load='3rou' size='340' side='right'caption='[[3rou]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3rou]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ROU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rou OCA], [https://pdbe.org/3rou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rou RCSB], [https://www.ebi.ac.uk/pdbsum/3rou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rou ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> | |||
==See Also== | |||
*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Knapp J]] | |||
[[Category: Lee JC]] | |||
[[Category: White MA]] | |||
Latest revision as of 12:32, 14 March 2024
Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)
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